Relationships between migraine and epilepsy: Pathophysiological mechanisms and clinical implications

Migraine and epilepsy are distinct neurological diseases with specific clinical features underlying pathophysiological mechanisms. However, numerous studies have highlighted the complex multifaceted relationships between two conditions. The headache manifest themselves in different ways. Firstly, diagnosis of these disorders may be challenging view possible overlapping. While post-ictal is a frequent condition, ictal epileptic rare but diagnosis. Both situations raise question mechanism triggered by seizures. aura can also exhibit overlapping symptoms leading to their misdiagnosis, particular case visual aura. Secondly, migraine occur as co-morbid particularly familial hemiplegic (FHM). From perspective, identification genetic mutations FHM has brought significant advances understanding dysfunctions neuronal networks hyperexcitability. purpose this review present encompassing that practice discuss such interactions.